Solitary myofibromas involving the skull have been rarely reported in the literature, and very few cases have presented outside infancy. Such lesions may mimic other osteolytic skull lesions, particularly eosinophilic granuloma.1-4 In this report, we describe the case of a six-year-old boy presenting with a solitary myofibroma of the skull.A previously healthy six-year-old boy presented with painless swelling in the left frontal region that had been slowly progressing in size over the past four months. The patient denied any accompanying systemic or neurological symptoms. On exam, a 2-cm firm lesion was palpable in the left parasagittal frontal region. The lesion was not tender to palpation and there was no surrounding inflammatory reaction. Neurological exam was unremarkable. A thorough general physical examination did not reveal any other similar lesions or lumps in the patient's body. Computed tomography scan of the head revealed aheterogeneous hypodense osteolytic lesion extending across the full thickness of the skull with possible involvement of the underlying dura. The lesion did not exhibit a trabecular pattern and had irregular, smooth, nonsclerotic margins (Figure 1).
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