Postprandial plasma adiponectin decreases after glucose and high fat meal and is independently associated with postprandial triacylglycerols but not with -11388 promoter polymorphism.

摘要

Adiponectin is suggested to regulate energy balance and insulin sensitivity. Several studies have indicated an association between fasting adiponectin and parameters of the metabolic syndrome. Because of the strong association of postprandial TAG metabolism with early insulin resistance syndrome, this study aimed to clarify the relationship between postprandial adiponectin and TAG, insulin and glucose in a population of 110 lean and obese subjects without diabetes. It also investigated the common promoter polymorphism -11 388 G/A for associations with fasting and postprandial parameters after a liquid fat load and a plain glucose challenge test. Serum adiponectin concn. after an oral glucose tolerance test and after ingestion of a standardized mixed, fat-containing meal was assessed. Fasting and postprandial adiponectin and the decrease of adiponectin were correlated with anthropometric and metabolic parameters. Subjects were genotyped for adiponectin -11 388 G/A promoter single nucleotide polymorphism. Adiponectin slightly decreased after both test meals. A significant decrease was attained 5 and 6 h after the lipid load and 2 h after the glucose load. Particularly, the mixed meal postprandial adiponectin showed stronger correlations with most traits of the metabolic syndrome than fasting adiponectin: postprandial adiponectin with HDL (r 0.30) vs. fasting adiponectin with HDL (r 0.23); with postprandial insulin (area under the curve): r -0.20 vs. r -0.16; with fasting insulin: r 0.10 vs. r 0.14; with BMI: r -0.23 vs. r -0.20; with waist: r -0.18 vs. -0.16; with systolic blood pressure: r -0.14 vs. r -0.12; and with diastolic blood pressure: r -0.18 vs. r -0.15. In multivariate analysis, postprandial TAG were the only independent predictor of adiponectin. There was no significant association of adiponectin, NEFA and TAG with -11 388 G/A adiponectin promoter polymorphism. These findings favour the interpretation that postprandial adiponectin has the strongest and independent associations to postprandial TAG metabolism. It could be suggested that a high-fat or high-glycaemic-index diet contributes to a decrease of adiponectin levels on a long-term basis.