Idiopathic Thrombocytopenic Purpura Associated With Graves disease: Unexpected Effects of Antithyroid Agent on Thrombocytopenia

摘要

A 40-year-old woman with Graves disease and idiopathic thrombocytopenic purpura (ITP) is described. After treatment with an antithyroid agent (methimazole), both the Graves disease and thrombocytopenia resolved. Since it is reported that thyroid stimulating hormone receptor antibodies (TRAb) may recognize antigens on both thyroid follicular cells and the platelet membrane, the decrease in the titer of TRAb by the immunomodulatory actions of methimazole may be responsible for the improvement in the thrombocytopenia.