A novel method for peptide block synthesis using unprotected peptides

Ishihama Y.; Oda Y.; Takenawa T.; Iwakura M.; Ito O.

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A novel method for peptide block synthesis using unprotected peptides

机译：使用未保护肽段合成肽段的新方法

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摘要

An S-cyanocysteine-mediated alpha-carbon activation reaction was used for the block synthesis of unprotected peptides. The repeated reaction using the S-cyanocysteinyl peptides as building blocks made it possible to ligate several peptide segments in order to synthesize larger peptides with natural amide bonding. (C) 1999 Elsevier Science Ltd. All rights reserved. [References: 10]

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《Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry》 |1999年第17期|共4页
作者
Ishihama Y.; Oda Y.; Takenawa T.; Iwakura M.; Ito O.;
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正文语种 eng
中图分类有机化学;
关键词
Chemical ligation; Hiv-1 protease; Cysteine; Proteins;

机译：化学连接;Hiv-1蛋白酶;半胱氨酸;蛋白质;

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专利

1. A novel method for peptide block synthesis using unprotected peptides [J] . Ishihama Y., Oda Y., Takenawa T., Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 1999,第17期

机译：使用未保护肽段合成肽段的新方法
2. UNPROTECTED PEPTIDES AS BUILDING BLOCKS FOR THE SYNTHESIS OF PEPTIDE DENDRIMERS WITH OXIME, HYDRAZONE, AND THIAZOLIDINE LINKAGES [J] . Shao J., Tam JP. Journal of the American Chemical Society . 1995,第14期

机译：未经保护的肽作为砌块，用于合成具有氧肟酸，氢酮和噻唑烷键的肽类侧基
3. PEPTIDE SYNTHESIS USING UNPROTECTED PEPTIDES THROUGH ORTHOGONAL COUPLING METHODS [J] . Tam JP, Lu YA, Liu CF, Proceedings of the National Academy of Sciences of the United States of America . 1995,第26期

机译：通过正交偶联方法使用未保护的肽合成肽
4. The use of a free peptide for preparation of a C-terminal building block for polypeptide synthesis in combination with a peptide thioester [C] . Saburo Aimoto, Kenta Teruya, Koki Hasegawa, the International Peptide Symposium . 2001

机译：使用自由肽用于制备用于多肽合成的C末端构建块与肽硫酯组合
5. The synthesis and characterization of novel biomaterials from natural building blocks: Biomaterials research: Past, present, and future directions, and, Saccharide-derived polymers as protein resistant biomaterials, and, Saccharide-peptide copolymers for gene delivery applications, and, Saccharide-peptide copolymer hydrogels for extracellular scaffold design. [D] . Metzke, Mark Adam. 2006

机译：从天然构件中合成和表征新型生物材料：生物材料研究：过去，现在和未来的方向，以及，糖衍生的聚合物作为抗蛋白质生物材料，以及用于基因传递应用的糖肽共聚物，以及糖肽共聚物水凝胶用于细胞外支架设计。
6. Peptide synthesis using unprotected peptides through orthogonal coupling methods. [O] . J P Tam, Y A Lu, C F Liu, 1995

机译：使用未保护的肽通过正交偶联方法合成肽。
7. Peptide synthesis using unprotected peptides through orthogonal coupling methods. [O] . Tam, J P, Lu, Y A, Liu, C F, 1995

机译：使用未保护的肽通过正交偶联方法合成肽。

A novel method for peptide block synthesis using unprotected peptides

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