Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci

摘要

Blood pressure (BP) is a major, modifiable determinant of cardiovascular disease (CVD) risk. Hypertension (MIM 145500) increases risk for a variety of sequelae, including coronary artery disease, heart failure (MIM 608320), stroke (MIM 601367), and peripheral vascular disease (MIM 606787). Heritability of daytime ambulatory BP from twin studies has been estimated to be approximately 50%-60% and -40% in family studies. Several studies have been performed to elucidate underlying genetic factors for BP, including genome-wide association studies (GWASs), meta-analyses, and admixture mapping.