Response to Iliff et al.

摘要

We thank Iliff et al. for their interest in our work, and we are pleased to reply. We reported that a mutation in MIR184 (MIM 613146) causes autosomal-dominant kera-toconus with early-onset anterior polar cataracts (KTCNCT [MIM 614303]) in a large Irish family.1 The corresponding authors described a US family with a similar ocular pheno-type of endothelial dystrophy, iris hypoplasia, congenital cataracts, and stromal thinning (EDICT syndrome), a phenotype which they have since found to be caused by the same mutation.2 We do not know whether the mutations have arisen independently or whether the families are distantly related.