D-Cycloserine Combined With Cue Exposure Therapy Fails to Attenuate Subjective and Physiological Craving in Cocaine Dependence

摘要

Background: Based on preclinical studies showing that the partial N-methyl-D-aspartate (NMDA) agonist D-cycloserine (DCS) facilitates extinction of cocaine self-administration and cocaine-induced conditioned place preference, we evaluated whether 50 mg of DCS would reduce craving to cocaine cues when combined with cue exposure (CE) in cocaine dependent humans.