Images in dermatology. A plethora of protein. Primary localized cutaneous nodular amyloidosis.

摘要

A 61-year-old man had long been plagued by symptoms of atopy and connective tissue disease when he presented with an 18-month history of soft, compressible nodules on both shins. His past history included atopic eczema since adolescence, asthma, hay fever, and hypertension. Two years earlier he experienced spontaneous venous thrombosis in the right arm. He also had elements of CREST syndrome, a constellation that includes calcinosis, Raynaud's syndrome, esophageal dysmo-tility, sclerodactyly, and telangiectasias. Our patient had a 10-year history of Raynaud's phenomenon, facial telangiectasias, reduced oral aperture, and esophageal reflux.