Stereospecific synthesis and absolute configuration of the (2S,3S,4S)-isomer of 2-methyl-2-(carboxycyclopropyl)glycine (MCCG)

Pajouhesh H.; Curry K.; Meresht MH.; Patrick B.

首页> 外文期刊>Tetrahedron, Asymmetry: The International Journal for Repid Publication on all Aspects of Asymmetry in Orgainc, Inorganic, Organometallic, Physical and Bio-Organic Chemistry >Stereospecific synthesis and absolute configuration of the (2S,3S,4S)-isomer of 2-methyl-2-(carboxycyclopropyl)glycine (MCCG)

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Stereospecific synthesis and absolute configuration of the (2S,3S,4S)-isomer of 2-methyl-2-(carboxycyclopropyl)glycine (MCCG)

机译：2-甲基-2-（羧基环丙基）甘氨酸（MCCG）的（2S，3S，4S）异构体的立体定向合成和绝对构型

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The conformationally restricted metabotropic glutamate receptor antagonist (2S,3S,4S)-2-methyl-2-(carboxycyclopropyl)glycine 1 (MCCG) has been synthesized in a stereoselective manner (>99% ee) with the (2S 3S,4S) absolute configuration of this molecule being confirmed by X-ray crystallographic analysis. Subsequent physico-chemical studies were undertaken and the data are at odds with those of the commercially available product. (C) 2003 Elsevier Science Ltd. All rights reserved. [References: 15]

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《Tetrahedron, Asymmetry: The International Journal for Repid Publication on all Aspects of Asymmetry in Orgainc, Inorganic, Organometallic, Physical and Bio-Organic Chemistry》 |2003年第5期|共4页
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Pajouhesh H.; Curry K.; Meresht MH.; Patrick B.;
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正文语种 eng
中图分类有机化学;
关键词
Metabotropic glutamate receptors; Acid; Isomers; Potent;

机译：代谢型谷氨酸受体;酸;异构体;有效;

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1. Stereospecific synthesis and absolute configuration of the (2S,3S,4S)-isomer of 2-methyl-2-(carboxycyclopropyl)glycine (MCCG) [J] . Pajouhesh H., Curry K., Meresht MH., Tetrahedron, Asymmetry: The International Journal for Repid Publication on all Aspects of Asymmetry in Orgainc, Inorganic, Organometallic, Physical and Bio-Organic Chemistry . 2003,第5期

机译：2-甲基-2-（羧基环丙基）甘氨酸（MCCG）的（2S，3S，4S）异构体的立体定向合成和绝对构型
2. A novel Wittig reaction of oxazolidinones: Stereospecific synthesis of N-BOC-(3S,4S)-statine and N-BOC-(3S,4S)-AHPPA [J] . Reddy GV., Iyengar DS., Rao GV. Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 1999,第4期

机译：恶唑烷酮的新型Wittig反应：N-BOC-（3S，4S）-Statine和N-BOC-（3S，4S）-AHPPA的立体定向合成
3. 2R,3S)-(+)- and (2S,3R)-(-)-Halofuginone lactate: synthesis, absolute configuration, and activity against Cryptosporidium parvum. [J] . Linder MR, Heckeroth AR, Najdrowski M, Bioorganic and Medicinal Chemistry Letters . 2007,第15期

机译：2R，3S）-（+）-和（2S，3R）-（-）-卤代夫酮酮乳酸：合成，绝对构型和对小隐孢子虫的活性。
4. Study on synthesis of (2S,3S)-2-methyl-3-((triethylsilyl)oxy)pentanal [C] . Shenkun Yang, Tianxiang Xu, Shuangping Huang, International Conference on Machinery, Materials Engineering, Chemical Engineering and Biotechnology . 2016

机译：（2S，3S）-2-甲基-3 - （（三乙基甲硅烷基）氧积）戊醛的研究研究
5. Scattering of electrons by atomic systems with configurations (1s)2 (2s)2 (2p)6 (3s) 2 (3p)9. [D] . Conneely, Michael Joseph. 1969

机译：电子通过原子系统（1s）2（2s）2（2p）6（3s）2（3p）9的原子散射。
6. Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells. [O] . Y. Hayashi, Y. Tanabe, I. Aramori, 1992

机译：2-（羧基环丙基）甘氨酸异构体的激动剂分析用于克隆在中国仓鼠卵巢细胞中表达的代谢型谷氨酸受体亚型。
7. ABSOLUTE CONFIGURATION OF 4-AMINO-3-HYDROXY-6-METHYLHEPTANOIC ACID PRESENT IN PEPSTATIN A AND STEREOSPECIFIC SYNTHESIS OF ALL FOUR ISOMERS [O] . MITSUHIRO KINOSHITA, SHIMPEI ABURAKI, AKITO HAGIWARA, 1973

机译：胃蛋白酶A和立体合成的4-氨基-3-羟基-6-甲基庚酸的绝对结构和所有四个异构体的立体合成
8. Calculation of the Total Electron Excitation Cross Section in the Born Approximation Using Slater Wave Functions for the Li (2S Yields 2P), Li (2S Yields 3P), NA (3S Yields 4P), MG (3P Yields 4S), Ca (4S Yields 4P) and K (4S Yields 4P) Excitations [R] . Simsic, P. L. 1974

机译：利用slater波函数对Li（2s产率2p），Li（2s产率3p），Na（3s产率4p），mG（3p产率4s），Ca（4s产率）的Born近似计算总电子激发截面4p）和K（4s产率4p）激发

Stereospecific synthesis and absolute configuration of the (2S,3S,4S)-isomer of 2-methyl-2-(carboxycyclopropyl)glycine (MCCG)

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