Preoperative prostate-specific antigen isofonn p2PSA <= 22.5 pg/ml predicts advanced prostate cancer in patients undergoing radical prostatectomy

摘要

Background: The prediction value of prostate-specific antigen (PSA) isoform [-2]proPSA (p2PSA) for detecting advanced prostate cancer (PCa) remains unclear. Our objective was to evaluate the additional clinical utility of p2PSA compared with total PSA (tPSA), free PSA (fPSA), and preoperative Gleason score (GIs) in predicting locally advanced PCa (pT3/T4) with high-accuracy discrimination The aim was to develop a novel classification based on p2PSA and preoperative GIs for predicting advanced PCa.