AHAS enzyme platform:genesis of C-C building blocks and chiral alpha-hydroxy ketones

摘要

Genetically engineered Acetohydroxy acid synthase (AHAS ) enzymes constitute a platform technology which can be used to generate a wide range of Chiral alpha-hydroxy ketones by acyloin condensation involving pyruvic acid and an aromatic aldehyde.The conversion is stoichiometric and without byproducts.The enzymes are also capable of generating intermediates which could end up as petroleum industry intermediates offering a "green" alternative to scarce petroproducts.