PROCESS FOR PREPARING CHIRAL AROMATIC ALPHA-HYDROXY KETONES USING 2-HYDROXY-3-OXOACID SYNTHASE

摘要

A biotransformation process for preparing chiral aromatic -hydroxy ketones in high yields is described, using 2-hydroxy-3-oxoacid synthase, such as AHAS or TSAS. Optionally substituted arylaldehydes and -oxoacids react in this process to provide pure enantiomers, useful as synthons in the production of various drugs, an example being (R)-phenylacetyl carbinol.