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Process for preparing chiral aromatic alpha-hydroxy ketones using 2-hydroxy-3-oxoacid synthase
Process for preparing chiral aromatic alpha-hydroxy ketones using 2-hydroxy-3-oxoacid synthase
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机译:使用2-羟基-3-草酸合酶制备手性芳族α-羟基酮的方法
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摘要
A biotransformation process for preparing chiral aromatic-hydroxy ketones in high yields is described, using 2-hydroxy-3-oxoacid synthase, such as AHAS or TSAS. Optionally substituted arylaldehydes and -oxoacids react in this process to provide pure enantiomers, useful as synthons in the production of various drugs, an example being (R)-phenylacetyl carbinol.
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