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Ultrasound promoted protection of alcohols: An efficient solvent-free pathway for the preparation of silyl ethers in the presence of no additive

机译:超声波促进醇的保护:在无添加剂的情况下制备甲硅烷基醚的有效无溶剂途径

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摘要

Various types of alcohols and phenols were rapidly protected by hexamethyidisilazane in good to excellent yields at room temperature using high-intensity ultrasound irradiation in the presence of no solvent or any additive. Good to excellent chemoselectivity was observed for competitive protection of hydroxyl groups in favor of sterically less hindered alcohols. Exclusive protection of phenols in the presence of aromatic amines was also demonstrated successfully. (c) 2006 Elsevier B.V. All rights reserved.
机译:室温下,在无溶剂或任何添加剂的情况下,使用高强度超声辐照,六甲基甲硅烷基氮杂能够以良好至极佳的收率迅速保护各种类型的醇和酚。对于羟基的竞争性保护有利于空间受阻较少的醇,观察到良好至优异的化学选择性。还成功地证明了在芳香胺存在下对苯酚的独家保护。 (c)2006 Elsevier B.V.保留所有权利。

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