Preparation of Silyl Ethers Using Hexamethyldisilazane in the Presence of N-Bromosuccinimide under Mild and Solvent-Free Conditions

摘要

A mild,simple,novel and highly efficient method for the rapid protection of various primary,secondary,tertiary aliphatic and aromatic alcohols using hexamethyldisilazane (HMDS) in the presence of N-bromosuccinimide (NBS) as an active,inexpensive,non-toxic and readily available catalyst under solvent-free conditions is described.Trimethylsilyl ethers were prepared in high to excellent yields with short reaction time under mild and almost neutral reaction conditions.