Aspirin and primary cardiovascular prevention:Uncertain balance between benefits and risks

摘要

Most individuals with no pre-existing cardiovascular disease have a low risk of experiencing arterial thrombosis. Using the standard Prescrlre methodology, we reviewed the literature on the risk-benefit balance of aspirin in the primary prevention of cardiovascular events.In the general population, a meta-analysis in 95 456 persons suggests that aspirin has no effect on either total or cardiovascular mortality. Aspirin may slightly reduce the risk of stroke in women and myocardial infarction in men, but it increases the risk of bleeding. It is unclear whether the benefits outweigh the risks.