FT-IR Spectrophotometric Analysis of Coenzyme Q10(CoQ10)and its Pharmaceutical Formulations

摘要

A Fourier transform infrared(FT-IR)spectrometric method was developed for the rapid,direct measurement of coenzyme Q10(CoQ10)in different pharmaceutical products.Conventional KBr spectra were compared for the best determination of active substance in drug preparations.Lambert-Beer's law and two chemometric approaches,partial least squares(PLS)and principal component regression(PCR+)methods,were used in data processing.