Decylglucoside microemulsion systems containing coenzyme Q10: Formulation, physicochemical characterization and stability

摘要

This study aimed to develop green microemulsions (MEs) for loading coenzyme Q10 (CoQ10). Decylglucoside, a surfactant in the group of alkyl polyglycosides (APG), was used in the formulations since it is biodegradable and non-ionic, leading to low toxic products and friendly properties to the environment. Two blank MEs, i.e., Ml and M2 were prepared by simple mixing dicaprylyl ether, decylglucoside, sorbotan monolaurate and water in the concentrations of 70%, 2.5%, 22.5% and 5%, respectively for Ml and 60%, 6%, 24% and 10%, respectively for M2. Afterwards, Ml and M2 were incorporated with 5% CoQ10 to obtained QM1 and QM2, respectively. All samples were studied for physicochemical properties and stability under accelerated condition. It was found that they were transparence and absence of liquid crystals. Their rheological profiles indicated low viscosity and Newtonian flow. After stability test by freeze thaw for 5 cycles, physicochemical properties of Ml, M2, QM1 and QM2 were not obviously different from those at the initial. In addition, more than 97% of label amount of CoQIO were found in both QM1 and QM2 after stability study. The results indicated that the investigated decylglucoside MEs were suitable systems for incorporation with CoQ10.