The SPR-based biosensor test system for analysis of small compounds interaction with human cytochrome P450 51A1 (CYP51A1)

Gnedenko O.V.; Kaluzhskiy L.A.; Molnar A.A.; Yantsevich A.V.; Mukha D.V.; Gilep A.A.; Usanov S.A.; Stonik V.A.; Ivanov A.S.; Lisitsa A.V.; Archakov A.I.

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The SPR-based biosensor test system for analysis of small compounds interaction with human cytochrome P450 51A1 (CYP51A1)

机译：基于SPR的生物传感器测试系统，用于分析小化合物与人细胞色素P450 51A1（CYP51A1）的相互作用

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The SPR-based test for human cytochrome P450 51A1 (CYP51A1) ligand screening has been developed. Applicability of this system has been validated with known azole inhibitors of cytochromes P450. The studied azoles selectively interacted with human cytochrome P450 51A1, which showed the highest affinity towards ketoconazole. The efficiency of the SPR based assay has been tested using 19 steroid and triterpene compounds, which have not been investigated as potential ligands of CYP51A1.

机译：已开发出基于SPR的人类细胞色素P450 51A1（CYP51A1）配体筛选测试。该系统的适用性已经用已知的细胞色素P450的唑类抑制剂进行了验证。研究的吡咯与人细胞色素P450 51A1选择性相互作用，后者对酮康唑的亲和力最高。已使用19种类固醇和三萜类化合物测试了基于SPR的测定的效率，尚未研究它们是否为CYP51A1的潜在配体。

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《Biochemistry (Moscow). Supplement, Series B. Biomedical chemistry》 |2013年第3期|共9页
作者
Gnedenko O.V.; Kaluzhskiy L.A.; Molnar A.A.; Yantsevich A.V.; Mukha D.V.; Gilep A.A.; Usanov S.A.; Stonik V.A.; Ivanov A.S.; Lisitsa A.V.; Archakov A.I.;
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正文语种 eng
中图分类生物化学;
关键词
atherosclerosis; azoles; CYP51A1 inhibitors; human cytochrome P450 51A1 (CYP51A1); interaction screening; SPR-based test-system assay;

机译：动脉粥样硬化;唑类;CYP51A1抑制剂;人细胞色素P450 51A1（CYP51A1）;相互作用筛选;基于SPR的测试系统分析;

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专利

1. The SPR-based biosensor test system for analysis of small compounds interaction with human cytochrome P450 51A1 (CYP51A1) [J] . Gnedenko O.V., Kaluzhskiy L.A., Molnar A.A., Biochemistry (Moscow). Supplement, Series B. Biomedical chemistry . 2013,第3期

机译：基于SPR的生物传感器测试系统，用于分析小化合物与人细胞色素P450 51A1（CYP51A1）的相互作用
2. Drug-drug interactions evaluated by a highly active reconstituted native human cytochrome P4503A4 and human NADPH-cytochrome P450 reductase system. [J] . Haehner T, Refaie MO, Muller Enoch D Arzneimittel-Forschung: =Drug Research . 2004,第1期

机译：通过高度活性的重组天然人细胞色素P4503A4和人NADPH-细胞色素P450还原酶系统评估了药物之间的相互作用。
3. Interactions of melatonin with the liver microsomal cytochrome P450 system of rats and humans in vitro and effects on the P450 system and the antioxidative status in rat liver after acute treatment. [J] . Klinger W, Karge E, Demme U, European journal of drug metabolism and pharmacokinetics . 2001,第1a2期

机译：褪黑素与大鼠和人类肝脏微粒体细胞色素P450系统的相互作用以及急性治疗后对大鼠肝脏P450系统和抗氧化状态的影响。
4. Assessment of Some Pesticides Interactions with Human Cytochrome P450: CYP2C8, CYP2C9 and CYP2C19 by Molecular Docking Approach [C] . Alecu Ciorsac, Diana Larisa Vl?doiu, Charline Fagnen, Balkan Physical Union., International Conference . 2016

机译：评估一些农药与人细胞色素P450的相互作用：CYP2C8，CYP2C9和CYP2C19通过分子对接方法进行评估
5. Docking and cheminformatic analysis of protein-ligand interactions: Cytochromes P450 (2D6 and P450cam) and estrogen receptors from human and zebrafish. [D] . Costache, Aurora Demetrina. 2006

机译：蛋白质-配体相互作用的对接和化学信息学分析：人类和斑马鱼的细胞色素P450（2D6和P450cam）和雌激素受体。
6. Testing the Pharmacokinetic Interactions of 24 Colonic Flavonoid Metabolites with Human Serum Albumin and Cytochrome P450 Enzymes [O] . Violetta Mohos, Eszter Fliszár-Nyúl, Beáta Lemli, 2020

机译：测试24种结肠类黄酮代谢物与人血清白蛋白和细胞色素P450酶的药代动力学相互作用
7. The screening of the inhibitors of the human cytochrome P450(51) (CYP51A1): the plant and animal structural lanosterol's analogs [O] . L.A. Kaluzhskiy, O.V. Gnedenko, A.A. Gilep, 2014

机译：筛选人细胞色素P450（51）（CYP51A1）的抑制剂：植物和动物结构Lanteroll的类似物

The SPR-based biosensor test system for analysis of small compounds interaction with human cytochrome P450 51A1 (CYP51A1)

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