A cDNA Encoding Geranylgeranyl Pyrophosphate Synthase from White Lupin

摘要

GGPP synthase (dimethylallyl transferase [EC 2.5.1.1],' geranyl transferase [EC 2.5.1.10], and farnesyl transferase [EC 2.1.5.30]) catalyzes the sequential l'-4 condensation of three molecules of IPP with the homoallylic dimethylallyl PPi to produce GGPP. Geranyl PPi and FPP are intermediates of this stepwise reaction and can act as substrates for condensation with IPP to produce GGPP. GGPP synthase is an important branch point enzyme in terpenoid biosynthesis, and GGPP is involved in the biosynthesis of diterpenes and carotenoids (Kuntz et al., 1992) as well as in protein prenylation (Rilling et al., 1990).