Cytochrome P450 2D6.

摘要

The cytochrome P450 2D6 (CYP2D6) is an enzyme of great historical importance for pharmacogenetics and is now thought to be involved in the metabolism of up to 25% of the drugs that are in common use in the clinic [1]. Several years before the gene was cloned, researchers observed that Caucasian population responded in a bimodal pattern to certain drugs such as debrisoquine and sparteine [2,3], with most patients exhibiting 'normal' pharmacokinetics, whereas others seemed to have great difficulty in metabolizing debrisoquine or sparteine. Debrisoquine and sparteine became examples of so-called probe drugs, and were used to phenotype patients [4].