Pharmacoepidemiological assessment of drug interactions with vitamin K antagonists.

摘要

The approach successfully identified an interaction between tramadol and VKA. However, associations observed for other drugs with no known VKA interaction suggest that the current approach may have too low specificity to be useful as a screening tool, at least for drugs for which time-varying confounding may be present. Copyright ? 2014 John Wiley & Sons, Ltd.