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上海交通大学学报：医学英文版

上海交通大学学报：医学英文版

本刊是医药卫生类综全性的高级学术期刊，国内外公开发行。本刊登载我校基础医学院、各附属医院、临床医学院、研究所（室）广大教师、医卫科技人员及校友的英文法文来稿。
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上海交通大学学报：医学英文版 >2013年第1期

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  • 摘要：The purpose of this experiment is to investigate the effect of pulsed electromagnetic field (PEMF) and biomechanical force on orthodontic tooth movement by means of measurement of gross tooth movement anatomic data, light microscopic evaluation and transmission electromicroscopic evaluation. The results indicate that PEMF combined with biomechanical force could accelerate the rate and amount of orthodontic tooth movement, enhance bone deposition in tension side and resorption in compression side. The results also suggest that PEMF could accelerate orthodontic tooth movement as a result of increase in quantity of active cells, PEMF couldn’t change the ultrastructure of cells.
  • 摘要：A human primary gastric cancer tissue （adenocarcinoma Ⅱ—Ⅲ） was transplanted into nude mice （SWISS/DF, nu/nu）. It has been transfered for 8 generations at 56 sites in 28 nude mice with transplanting rate of 100%. The transplanted tumor is designated as transplanted human primary gastric cancer-1 in nude mice （THPGC-1）. The growth rate of THPGC-1 is rather rapid and the size of transplanted tumor reaches 1cm2 in 4—5 weeks after transfer. The morphology and histochemistry of the original tumor were retained well in the initial and serial transplanted tumors. THPGC-1 could secrete carcinoembryonic antigen （CEA）. After intravenous or intraperitoneal injection of 131Ⅰ-antiCEA monoclonal antibody into the THPGC-1 bearing nude mice, the radiolabeled antibody was concentrated and localized in the tumor as shown by γ-camera analysis. Similar pattern of lactate dehydrogenase isoenzyme was observed both in primary gastric cancer tissue and THPGC-1 tissue. Chromosomal examination revealed that THPGC-1 was human aneuploid ones. Southern blot analysis showed that the pattern of repetitive DNA bands and the structure of 28S rDNA, c-H-ras and c-myc genes in THPGC-1 were identical to the original primary gastric cancer DNA. The results suggest that THPGC-1 be a reliable model for the research of the molecular biology of cancer cells and experimantal gastric cancer diagnosis and treatment.
  • 摘要：Ninety-four pathologic specimens of gastric mucosa with lesions including simple intestinal metaplasia, intestinal types of mild, moderate, severe dysplasia and gastric carcinoma were submitted to morphometric analysis by an automated image analysis system. Four kinds of indices and four geometric parameters were measured. They were: (1) Index of Structural Atypism (ISA); (2) Index of Glandular Formation (IGF); (3) Index of Nuclei-Gland ratio (ING); (4) Widthen of Nuclear Band (WNB); (5) Geometric parameters of cell nuclei: including Area, Perimeter, Mean Diameter, and Contour. Apart from Contour, these variables were increased with increasing degrees of atypism in the various types of gastric mucosal lesions. Hence the indices and parameters may be used as objective diagnostic criteria. An assessment model was established for discriminating various types of lesions. The coincidence rate between the model assessment and the original histopathologic diagnosis was 86.1%. Morphometric analysis may provide a means of standardizing pathologic diagnosis and grading of gastric precancerous lesions.
  • 摘要：Mortality rate of gastric cancer is about 20.93/100000 which is the highest malignancy in China. The scientist of our country are at present interested in studying the postoperative survival model by multivariate analysis method just as stepwise regression model. The proportional hazard model initiated by Cox (1972) is more advanced than other regression method which is unneccessary to suppose the distribution of survival time and easy to analyse censoring data (the latter is difficult). This paper presented the first time application of Cox model in survival analysis of gastric cancer in China. The survival analysis system (SAS-Ⅰ) software complied by the author includes multivariate anlysis by Cox model, PV analysis and estimation of survival function which could provide useful information to surgeon for treatment of cancer patients.
  • 摘要：Gastric cancer remains one of the leading malignancies in China. The history of modern surgical treatment of gastric cancer could be dated back to the early fifties with an overall 5-year survival rate of around 10%. Remarkable progress has been achieved ever since in terms of operability, resectability and 5-year survival rate which ranges now from 30% to over 50% after radical resection. In regard to problems and future perspective, apart from the effort which should be redoubled in increasing the detection rate of EGC, the need to popularize the new international TNM staging system, to carry out in-depth studies on the biological behavior of gastric cancers and the role of the spleen in the evolution of gastric cancer, and to include new potential adjuvant measures in the therapeutic regimen of AGC are emphasized.
  • 摘要：The expression of several protooncogenes was detected in three different differentiated gastric cancer cell lines (MKN28, MKN45, SGC7901) and 5 specimens from 5 human primary gastric cancers at cellular level by in situ hybridization. The data indicated that there were high levels of c-Ha-ras expression in both cell lines and tumor tissues as compared with control samples. But the transcripts of c-myc and c-erbB were rather low. The results suggested that Ha-ras be involved in or associated with the gastric cancer. There were another two interesting findings: (1) The levels of c-Ha-ras was different among the individual cancer cells within a single gastric cnacer. (2) Some inflammatory cells in the tumor tissuse and normal tissues adjacent to the cancer displayed high level of c-Ha-ras expression. Those two phenomena are worthwhile for further study.
  • 摘要：In November 14—16,1988,the Shanghai Institute of Djgestive Disease(SIDD) of the Shanghai Second Medical University(SSMU) sponsored the First International Symposium on Gastrointestinal Cancers at Shanghai. The symposium was held very successfully with 500 participants and presented 240 scientific papers. of the 500 participants,more than 100
  • 摘要：Gastric cancer is the leading cause in the deaths caused by cancer in China. The highest level area of mortality of gastric cancer is located in the eastern and northern China, such as Qinghai, Ningxia, Gansu Provinces, etc, while the lowest mortality area is located in Guangdung and Guangxi Provinces, In recent years the mortality of gastric cancer tends decrease steadily. The sex ratio is 2.06:1 (male:female), the mortality of gastric cancer remarkably increases at the age after 35 years old. The mortality of the minority nationality of Kazak is the highest, while that of the Miao nationalily is the lowest. The lower the level of economic income, the higher the mortality of gastric cancer is. There is also a relationship between the profession and the mortality of gastric cancer. The dietary factors are very important in the occurrence of gastric cancer: salted food, lack of protein, lack of fresh vegetables and fruits, irregular dietary habits, over eating at one time, heavy salty taste, eating quickly, eating piping hot food, eating hard food, etc; these factors are high risk factors of gastric cancer. Mentally, as having suffered severe mental impaction, often burdened of unhappy things, and belonging to the depressive mental type, these are high risk factors also. The distribution of mortality of gastric cancer is related to the display of the tertiary period stratum, and to the amount of intake of trace elements such as Zn, Ni, Se, etc. There is also a relationship between the occurrence of gastric cancer and chronic atrophic gastritis. The preventive measures of gastric cancer are: less or not intake of salted food; avoidance of heavy salty taste; more intake of rich protein food such as fresh meat, fish, eggs, milk and soybean products; taking more fresh vegetables and fruits; keeping an optimistic view at any time; improving water quality, etc.
  • 摘要：The allelic distribution of EcoRI and BamHI fragments of ras family genes between the human primary gastric cancer tissues and the corresponding adjacent normal tissues did not show any differences. Three genotypes of BamHI restriction fragment length polymorphism of c-H-ras were revealed. No significant differences in the RFLPs were observed between normal individuals and gastric cancer patients. Four protooncogenes, c-H-ras, N-ras, c-myc and c-fos, were found to be transcriptionally active in the gastric cancer tissues in some cases examined. The comparison of the expression of these oncogenes between the malignant tissues and the corresponding normal tissues showed differential patterns. The expression of c-H-ras at cellular level was detected by in situ hybridization. The enhanced expression of c-H-ras in the gastric cancer cells was demonstrated, but the degree of the expression among the cancer cells was shown to be heterogeneous. In addition, the enhanced expression of c-H-ras was seen in the inflammatory cells.
  • 摘要：In patients with gastric carcinoma the determination of the activities of some cellular and humoral factors may reflect the immunological state of the patient, the stage and extent of the disease, and help estimate the effects of treatment and prognosis. Moreover, experimental studies and preliminary clinical trials of some of these cellular elements and humoral factors in the treatment of gastric carcinoma have opened a new field of adoptive immunotherapy.
  • 摘要：The multimodality treatment methods of rectal cancer in China are presented. Extended radical excisions are used for Dukes’ B and C cases to reduce local recurrence. These include: high ligation with clearance of proximal lymph nodes at origin of inferior mesenteric artery, lateral pelvic lymphadenectomy, posterior or total pelvic exenterations in selected cases; but controversy exists. Radical sphincter-saving resections are advocated to improve the quality of life. Prerequisites of sphincter-saving resection are adequate resection of bowel and mesentery distal to the lesion, depending on the macroscopic type of lesion and degree of differentiation. The decisive factor in the choice of type of operation is the length of rectal stump above levator ani after resection. Bacon’s pull through resection was modified by preservation of levator ani and dentate margin, much better functional results were obtained postoperatively. Transanal full thickness local excision is advocated for small, protuberant, mobile, well differentiated lesions below the peritoneal reflection. Pre- or postoperative adjuvant radiation therapy is sometimes used for Dukes’ B and C cases. Adjuvant 5-Fu chemotherapy is usually used intraoperatively (intraluminal) or postoperatively (intravenous). The superiority of preoperative intrarectal 5-Fu emulsionover the conventional intravenous route has been demonstrated by experimental and clinical studies, which showed much higher and lasting concentration of 5-Fu in the rectal wall tissues and mesenteric lymph nodes, and a much lower concentration of 5-Fu in bone marrow after intrarectal administration. Several surgical groups employed varying techniques of sphincteric reconstruction of perineal colostomy after abdominoperineal excision, utilizing the gracilis or gluteus maximus sling, or intussusception of the colonic stump; with favorable late results in reported cases. However, controversy exists, so strict appropriate case selection is emphasized to avoid unnecessary sacrifice of the normal anus.
  • 摘要：Endoscopic xenon ion laser induced autofluorescence spectra in various gastric diseases were tested in 104 patients diagnosed by endoscopy and biopsy, including 28 gastric cancer, 9 gastric ulcer, 46 chronic atrophic gastritis, and 21 superficial gastritis. The autofluorescence spectrum excited with the 365 nm line of pulsed xenon ion laser was measured. The xenon ion laser beam having an output energy of 0.5 mJ with a duration of 0.6μs and a repetition rate of 10 Hz was used as the excitation source. A coaxial optical cable for laser light and autofluorescent light transmission was inserted via the biopsy channel of an endoscope into the cavity of stomach. The tip of opitcal cable was aimed at the gastric tissue and autofluorescence spectrum was plotted on X-Y recorder. As the monochromator scanned in the range 500-750 nm, a single-pulse fluorescence spectrum could be obtained by using an optical multichannel analyser, and then this fluorescence spectrum was stored in the computer. The whole procedure could be completed within 15 seconds. The results of the present study show that autofluorescence spectra of gastric cancer have characteristic peaks near 630 nm and 690 nm, while no such peaks appear in the spectra of the corresponding normal regions. A consistency of 75% was observed in gastric cancer as compared with the pathologic diagnosis. It is claimed that this is a harmless, safe, simple, and fast procedure in the diagnosis of gastric cancer.
  • 摘要：We had given evidences of cytocidal effect in vitro of either parvovirus H-I(PV H-1) or AT-1840 (lycobetaine) on gastric cancer cells. They act on different phase of the cell cycle of the gastric cancer cells, with PV H-1 on the late stage of S phase and AT-1840 on M phase. Combined use of these drugs gives better killing effect than the individual drug alone. In gastric cancer-bearing nude mice (ascites and solid tumor forms), both AT-1840 and PV H-1 increased the survival peroids and decreased the size of solid tumors. Depsite these are the experimental study which may not to be the same in human being. However, the study has layed down a solid foundation for our further exploration of these two substances as anti-gastric cancer drugs in the future.
  • 摘要：Flow cytometric (FCM) and microspectrophotometric (MSP) measurements of cell nuclear DNA content were made in 53 fresh gastric carcinoma specimens and in 30 gastric mucosal specimens with chronic gastritis. DNA aneuploidy was found in 32/53 (60%) of gastric carcinomas, and appeared more frequently in wellor moderately differentiated tubular adenocarcinomas (90%) than in undifferentiated and mucousa cell carcinomas (23.6%) (P0.001). No aneuploidy was found in chronic gastritis samples, but their proliferative cell fractions were higher than in normal control gastric mucosa samples (P0.01). A comparison was made between FCM and MSP analyses of DNA content in 29 cases of gastric carcinoma, a high correlation rate (r=0.90) was found. The advantages and limitations of both methods are discussed, they may be used in combination for more precise cytochemical analysis.
  • 摘要：Measurement of DNA content and nuclear area by microspectrophotometry was performed in gastric carcinogenesis of three adult wolfdogs induced by N-ethyl-N’-nitro-N-nitrosoguanidine (ENNG). The mean values and standard deviations of nuclear DNA and area in different groups of lesions were as follows: normal gastric mucosal 0.03±2.30 AU and 28.76±5.85 μm~2; atrophic gastritis 12.04±3.34 AU and 28.69±8.02/μm~2; mild dysplasia 13.52±3.73 AU and 28.23±8.12μm~2; moderate dysplasia 20.88±4.57 AU and 47.58±10.74 μm~2; severe dysplasia 24.01±4.48 AU and 56.64±21.53μm~2; well-differentiated adenocarcinoma 33.07±9.38 AU and 72.99±15.57μm~2, respectively. The nuclear DNA content and nuclear area showed a significant difference statistically between normal gastric mucosa and gastric carcinoma (P0.01). The nuclear area of gastric carcinoma increased with DNA content (r=0.73, P0.01), and the distribution patterns of DNA content in the histogram showed that diploidy was decreased and polyploidy was increased in carcinoma. These findings indicate that DNA ploidy patterns and nuclear area could be a useful index in differentiated carcinoma and precancerous lesions.
  • 摘要：To determine the relationship between angina pectoris before myocardial infarction (MI) and the extent of coronary artery disease and collateral circulation, 28 patients with (group Ⅰ)and 22 patients without (group Ⅱ) angina one month prior to acute MI underwent left ventriculography and coronary arteriography within 6 months of a first transmural MI. 23 patients in group Ⅰbut only 6 patients in group Ⅱhad multivessel disease. Despite a similar incidence of total occlusion of infarct-related artery, the collateral score in group Ⅰwas significantly higher than that in group Ⅱ. Abnormal regional left ventricular motion score was lower in group Ⅰthan in group Ⅱ. The study suggests that a history of angina before MI may predict the presence o f multivessel disease and the formation of collateral circulation in patients with MI.
  • 摘要：The content of nickel of nitinol alloy isabout 50%, it is higher than that of 316 L stainless steel for surgical implantation, and lower than that of nickel based alloy for prosthetic dentistry. Nitinol alloy is implanted to the dog’s body, the effect of nickel in nitinol to the animal’s body is explored by the analyzing the trace element of nickel in the dog’s hair before and after implantation. Experimental results show that after 2 years implantation of nitinol alloy, the nickel content in the hair is not markedly increased. By measuring the weight, height and length of the animal periodically, and contrasting with normal data, no impairment of growth of the animal is observed. The ability of the animal to distinguish men and objects is also normal. The weighing test of the alloy sample taken out after 2 years implantation, shows that its anti-corrosion effect belongs to the very strong grade. It shows that during the long period of nitinol implantation into the animal’s body, there is no evidence that the free nickel or nickel compound present in tissue is harmful to the animal.
  • 摘要：The accumulation of extravascular lung water （EVLW） after cardiac surgery of congenital heart disease may predicted from the preoperative level of pulmonary blood flow. This accumulation of EVLW may adversely affect ventilatory parameters. Lung compliance （LC）, cardiac index （CI）, blood arterial oxygen tension （PaO2）, left atrial pressure （LAP）and EVLW were measured serially immediately postoperative in two groups of children after complete repair of congenital heart disease contrasted by their level of pulmonary blood flow: Tetralogy of Fallot （TOF, n=10, 4.6±1.9 years） and ventrvcular septal defect with pulmonary arterial hypertension （VSD+PAH, n=10, 5.4±2.0 years）.Using a double indicator-dilution technique （DIDT） the EVLW peaked at the 16th hour postoperation in TOF group and at the 8 th hour postoperation inthe VSD with PAH group. During the first 24 hours after surgery the EVLW was consistently higher in the VSD with PAH group （P0.01）. There was a negative correlation between the EVLW and LC, CI and PaO2 and no correlation between the EVLW and LAP. In three hypoxemic patients of the VSD with PAH group the LC deteriorated while the EVLW was elevated. After treatment with positive end expiratory pressure （PEEP） the hypoxemia corrected as the LC increased and the EVLW decreased, with no change in the CI. Thus, measurement of EVLW provides a sensitive method for explaining changes in LC, that may lead to a more rational adjustment of mechanical ventilator parameters.
  • 摘要：We studied the RSV specific IgE antibody, histamine and basophil from infants with RSV bronchiolitis and found during the acute phase either the titers of RSV-IgE or the concentration of histamine increased significantly, the number of basophil and basophil degranulation in the presence of RSV antigen also increased. In vitro studies revealed hypersensitivity participates in the pathogenesis of RSV bronchiolitis. We also found that infants with RSV bronchiolitis, the RSV-IgE persisted for a long time presumably this plays an important role in recurrent wheezing after RSV infection for years.
  • 摘要：The morrhuic acid suppository had been used in 1746 women with a total of 16073 women-months cycles. 1354 cases continued to use the suppository for 12 months, 367 cases completed 24 months and 15 cases 25-34 months. The cumulative twelve month life table pregnancy rate was 10.1 per 100 women and the method pergnancy rate was 4.8 per 100 women corresponding to an effective ness rate of 95.2% per 100 women. The gross twelve months cumulative termination rate per 100 women was 27.3 giving a continuation rate of 72.7%. Cervical smears were taken in 499 women showing no carcinomatous changes. It did not interfere with the menstrual cycle and flow. The only adverse side effect was the burning or itching sensation of the vulva which accounts for a 1.2% discontinuation rate. This suppository is sultable for contraception of all women in reproductive age.
  • 摘要：Intracellular free calcium of platelets and serum free calcium were studied in human essential hypertension. Intracellular free calcium of platelets was significantly higher in hypertensive patients than that in normotensive subjects, and this was correlated with blood pressure. There was no difference of serum free calcium between hypertensives and normotensive controls. Antihypertensive treatment with nifedipine resulted in a reduction of platelet free calcium, and this was correlated with the fall of blood pressure. In patients treated with clonidine, although there was no difference of platelet free calcium between hypertensives and normotensive controls, serum free clacium was significantly reduced. These results indicated that intracellular free calcium may be regulated by same hormonal or pharmacological factors which determined the height of blood pressure, calcium channel blockers may be more effective in prevention of cardiovascular and cerebrovascular complications caused by platelet hyperfunction in essential hypertension.
  • 摘要：Chromosome studies were observed on 23 adult cases with acute myelomonocytic (M4) or acute monocytic (M5) leukemias. Chromosome abnormalities were found in 7 cases, among whom 3 patients with M4 all revealed monosomy 7 or deletion 7, but one with inv (16). Rearrangement of chromosome 11 were not observed in the M5. The rate of complete remission and median survival for patients M4 under 60 years of age was higher and longer than that for those with M5 over 60 years old. The prognosis of M4 was usually good.
  • 摘要：The activity of α-1, 4-glucosidase in seminal plasma from 105 fertile Chinese was 42.7±2.0 mIU/ml and 136.5±8.1 mIU/total. The specific activity was 874.3±84.0 mIU/g protein. There was a significantly positive correlation between the activity (mIU/ml) and the number of spermatozoa. The activity for infertile group was lower than that of the fertile group. For the azoospermia group, the activity was 28.7±3.4 mIU/ml and 47.8±4.9 mIU/total (n=29). There was a significant difference as compared with that of fertile group. The enzyme activity of varicocele group was 35.6±5.1 mIU/ml and 120.3±13.6 mIU/total (n=18). It was higher than that of the azoospermia group (P0.001). There was no significant difference between the varicocele group and the fertile group. The possible role of the enzyme in seminal plasma and the significance of measurement of the activity in clinical investigation are discussed briefly.
  • 摘要：One hundred and twenty-three lumbosacral radiculography in 67 patients, with age range from 15 to 60 years, have been performed during 1984-1986. In this paper, the anatomical concept of the lumbosacral (L4, 5 and S1) nerve root canal and the technique of radiculography are reported. Basing on our results. we suggest different pathologic images of the nerve root canal. The indication and failing causes in performing radiculography are discussed. We believe that nerve root block would be of great diagnostic and therapeutic value in cases of lumbago and sciatica.
  • 摘要：Thoracic scoliosis was produced in 24 New Zealand rabbits by 2 methods of rib resection. Scoliosis was detected in X-ray film taken one month and 3 or 5 months after operation. Aortic blood specimens were obtained for gas analysis in 18 of the 24 animals. Out of the 18 animals, 5 had scoliosis with a curvature less than 15°, another 5 with a curvature between 18°-27°, while the remaining 8 with a curvature greater than 30°. The blood gas of the scoliotic rabbits was compared with that of 6 normal adult rabbits. With increase in scoliotic curvature the PaCO2 increased, while the PaO2 decreased. The PaCO2 and PaO2 of the group with curvature greater than 30°showed sigrificant difference as compared with those of the normal animals （P0.01 and P0.001 respectively ）, signifying a hypoxemia with severe scoliosis.Scoliotic curvature of patients greater than 30°constitutes an indication for surgical correction. As these scoliotic patients may have subclinical abnormal pulmonary function with potential danger of post-operative respiratory complication, orthopaedic surgeons should give them careful consideration before resorting to operation.
  • 摘要：In order to investigate the evolution of the venous patch blood inter face after implantation, an experimental model utilizing an autologous venous patch to repair an infrarenal abdominal aortic defect in rats was developed. A small piece of both the jugular vein and the aorta were first excised. After implantation and reestablishment of blood flow, the animals were subsequently sacrificed in groups of 3 at the following intervals: 10 seconds, 1, 10, 30 minutes, 1, 6, 12, 24 hours, 7, 30 and 90 days. All the patches and adjacent aortae were collected and studied using scanning electron microscopy. The results of our present show that: 1) the extensive endothelial lesion of both the autologous vein patch and the adjacent aorta is presented before implantation due to operative manipulation; 2) after blood flow reestablishment, the patch and the adjacent aortic interface are reactive to platelets and other blood cells; 3) the new cellular lining begins to appear from the 7th day after implantation, but it is not complete at 3 months; 4)from the model, the endothelial repair of autologous venous patch and its adjacent aorta is a very slow process.
  • 摘要：From August 1st 1976 to July 31st 1986, thirty—six (32.7%) of the 110 burn patients over the age of sixty—five admitted to the Bum Center, Ruijin Hospital died in hospital. Significant differences related to the total bum surface area (TBSA) and full-thickness burn size were observed between the survivors and the non-survivors. Among the causes of death, pre-existing cardio-pulmonary diseases and associated inhalation injury were particularly important since pneumonia was considered as a primary cause of death in 13 patients, myocardial in 2, cor pulmonale and heart failure in 2. Cautious in fluid resuscitation, early exisian of deep burn wound and grafting, prevention and treatment of a variety of life-threatening complications, and nutritional support appeared to be beneficial in decreasing the mortality of aged burn patients.
  • 摘要：Treacher Collins syndrome is caused by the maldevelopment of the first and second branchial arches. It is characterized by mandibulofacial dysostosis and has the following features: outward and downward obliquity of lateral canthi, colobomas of the lateral 1/3 of. the lower eyelids, flattening of malar bone, absence of zygomatic arches, a small and receding chin, sometimes accomapanied with small ears and cleft palate. In 8 cases, the authors reconstructed malar hypoplasia and micrognathia with bone graft and corrected the palpebral fissures. The results of this procedure are satisfactory.
  • 摘要：A study on incidence of phenylketonuria (PKU) by neonatal screening was done in Shanghai. Twenty-one cases of PKU out of 358767 newborns screened during 7 years were comfirmed with the incidence of about 1/17000. This incidence is very comparable with that in the western countries but much higher than that in Japan.
  • 摘要：Twenty-four rabbits were randomly divided into two groups: indomethacin group (Group A, n=12) and control group (Group B, n=12). Rabbits in septic shock had profound hypotension, hypoxia, leukocytopenia, thrombocytopenia, increased levels of lactate and prostaniods. Indomethacin (3 mg/kg) given 10 minutes after the occurrence of shock significantly improved the 24-hour survival of animals, rapidly reversed the hypotensive state of shock, increased the arterial oxygen pressure, partly prevented the increase of blood lactate, and decreased the level of prostaniods. Preliminary clinical trials also showed that indomethacin decreased the level of prostaniods and raised the blood pressure in pediatric patients with septic shock. It is clear that further clinical study is warranted.

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