Energetics of enzyme stability

摘要

Advances in computational protein engineering depend on the development of an accurate treatment of the interactions among the 'elementary constituent's of enzymes. most of the current research is focused on finding the right balance in the estimations of energy and entropy. We are making progress in tailoring Enzymatic function. There are currently Two main approaches, directed evolution [1] and rational design [2]. The latter method requires an accurate knowledge of the rules of macromolecular assembly and stability. Here is where biophysics can be most helpful to biotechnology because we need to specify how different parts of a molecule come together or, in other words, to control molecular energetics.