Synthesis and antibacterial activity of copper(II) complexes with sulphathiazole and cephalosporin ligands

摘要

Copper(II) reacts with cephalosporins plus sulphathiazole (Hstz) to form the following mixed complexes: [Cu(cefazol)(stz)(H2O)], [Cu(cephalot)(stz)(H2O)2], [Cu(cefotax)(stz)], [Cu(ceftria)(Hstz)] and [Cu(cefepime)(stz)Cl] (Hcefazol = cefazolin, Hcephalot = cephalothin, Hcefotax = cefotaxime and H2ceftria = ceftriaxone) which were characterized by physicochemical and spectroscopic methods. The spectra indicated that most of the cephalosporins are probably acting as monoanionic multidentate chelating agents, the exception being ceftriaxone which is dianionic. The complexes are insoluble in water and common organic solvents and probably have polymeric structures. They have been screened for activity against several bacteria, and the results are compared with the activity of cephalosporins.