Vitamin D receptor gene polymorphisms: no association with low bone mineral density in adolescent idiopathic scoliosis girls

摘要

Genetic factor has been proven to be one of the key factors in the etiology of adolescent idiopathic scoliosis (AIS), and osteopenia has been well documented in the AIS patients. Vitamin D receptor (VDR) gene polymorphism has been found to be associated with low bone mineral density (BMD) in adults. However, the VDR gene polymorphism has not been discussed in AIS patients.Blood samples were obtained from 146 AIS girls and 122 healthy girls. Anthropometnc parameters of AIS group including age, body height, weight and Cobb angle were all recorded. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to detect and analyze VDR gene distributions of AIS group and control group. BMD of the lumbar spine (L2-L4) and proximal femur were measured using dual energy x-ray absorptiometry in AIS group. The frequency of Bb genotype was significantly higher in patients than that in controls (P<0.01). The B alJele seemed to be overrepresented in patients compared with controls (P<0.01).There was no distinction among the lumbar spine and proximal femur BMD of each genotype in AIS group (P>0.05). VDR gene polymorphisms have no association with the low spine lumbar and proximal femur BMD in AIS girls.