The acute effects of fine particulate matter constituents on circulating inflammatory biomarkers in healthy adults

摘要

Background: Systemic inflammation is considered one of the key mechanisms in the development of cardiovascular diseases induced by fine particulate matter (PM_(2.5)) air pollution. However, evidence concerning the effects of various PM_(2.5) constituents on circulating inflammatory biomarkers were limited and inconsistent. Objectives: To evaluate the associations of short-term exposure to a variety of PM_(2.5) constituents with circulating inflammatory biomarkers. Methods: We conducted a panel study from May to October 2016 among 40 healthy adults in Shanghai, China. We monitored the concentrations of 27 constituents of PM_(2.5). We applied linear mixed-effect models to analyze the associations of PM_(2.5) and its constituents with 7 inflammatory biomarkers, and further assessed the robustness of the associations by fitting models adjusting for PM_(2.5) mass and/or their collinearity. Benjamini-Hochberg false discovery rate was used to correct for multiple comparisons. Results: The associations of PM2.5 were strongest at lag 0 d with tumor necrosis factor-α (TNF-α), at lag 1 d with interleukin-6, interleukin-8, and interleukin-17A, at lag 02 d with monocyte chemoattractant protein-1 (MCP-1) and intercellular adhesion molecule-1 (ICAM-1). After correcting for multiple comparisons in all models, Cl~-, K~+, Si, K, As, and Pb were significantly associated with interleukin-8; SO_4~(2-) and Se were marginally significantly associated with interleukin-8; SO_4~(2-), As, and Se were marginally significantly associated with TNF-α; and Si, K, Zn, As, Se, and Pb were marginally significantly associated with MCP-1. Conclusions: Our results suggested that some constituents (SO_4~(2-), Cl~-, K~+, and some elements) might be mainly responsible for systemic inflammation triggered by short-term PM2.5 exposure.