Urinary concentrations and distribution profiles of 21 phthalate metabolites in pet cats and dogs

摘要

Phthalates are widely used in several consumer products, including plastics, toys, cosmetics, and medical devices. Little is known about phthalate exposure in pet animals, however, even though they share an indoor environment with humans; this is the first study to measure such exposure. We measured 21 phthalate monoester metabolites (PhMs) in the wine of pet cats (n = 50) and dogs (n = 50) collected from New York State, USA. PhMs were widely detected in all samples, and 12 of 21 PhMs had detection frequencies (Dfs) 80%. The median urinary concentrations of total PhMs in pet cats and clogs were 630 ng/mL and 186 ng/mL, respectively. Monoethyl phthalate (mEP) was the most abundant compound in both cats and dogs. Phthalic acid (PA; a non-specific metabolite of phthalates) was found at very high concentrations in cats (median: 520 ng/mL). The estimated daily intake (EDI) and hazard quotient (HQ) for major phthalates in pets showed that DEHP exposures in cats and dogs were only 2-fold less than the US Environmental Protection Agency suggested reference dose (RID) for humans. (C) 2019 Elsevier B.V. All rights reserved.