Role of hypoxia-inducible factor-1α in hypoxia-induced expressions of IL-8, MMP-1 and MMP-3 in rheumatoid fibroblast-like synoviocytes

摘要

Objectives. Hypoxia-inducible factor-1α (HIF-1α) is a master regulator in the cellular response to hypoxic conditions, and rheumatoid synovial tissue is known to exist under hypoxic conditions. Therefore, this study was conducted to determine the contribution of HIF-1α to hypoxia-induced MMP and cytokine production in fibroblast-like synoviocytes (FLS).