Antioxidant activity of 5,8-dihydroxy-1,4-dihydro-1,4-methanonaphthalene

摘要

5,8-dihydroxy-1,4-dihydro-1,4-methanonaphthalene (DDMN), a substituted phenol, is synthesized by reduction of a cyclic dione, 1,4,4a,8a-tetrahydro-endo-1,4-methano-naphtha-5,8-dione (THMND). Pulse radiolysis technique has been employed to understand the nature of transient species formed on reaction of radiolytic species of water radiolysis with DDMN.?OH radicals were observed to react with DDMN with a bimolecular rate constant of 1.5×1010 dm3 mol?1 s?1. Inhibition of radiation induced lipid-peroxidation by DDMN was studied in rat liver microsomes by assessing the formation of thiobarbituric acid reactive substances (TBARS). It was found to be strongly inhibitory. The results suggest that DDMN has very good antioxidant activity and may possibly emerge as a good radio-protector.