Synthesis and micellization behavior of chiral amphiphilic diblock copolymers bearing amino acid/dipeptide pendants

摘要

Novel chiral amphiphilic diblock copolymers bearing L-phenylalanine or α-L-aspartyl-L-phenylalanine methyl ester pendants were synthesized using a "click" reaction. The structure and composition of copolymers were characterized by gel permeation chromatography, ~1H NMR, elemental analysis and optical rotation measurements, which showed that the synthetic route can produce copolymers with well-defined composition and optical activity. The results from surface tension measurements, dynamic light scattering, transmission electron microscopy and ~1H NMR spectra indicated that these chiral copolymers formed spherical micelles with an optically active hydrophobic core in a NaH_2PO_4 buffer (pH 4.5) system.