Antibiotic-ribosome complex structure conserved across species

摘要

Antibiotics that inhibit ribosomal translation in bacterial cells have proven to be potent therapeutics, but the increasing prevalence of antibiotic-resistant pathogens has diminished these drugs' effectiveness. Recent studies have shown that structure-based drug design can potentially address resistance mutations by chemically linking pairs of known classes of ribosomal inhibitors, but discrepancies between crystallographic models of the structure of antibiotic-ribosome complexes have impededrnhybrid molecule design.