A Cell Therapy for Chronic Wounds Based Upon a Plasma Polymer Delivery Surface

摘要

This contribution chronicles the research history over the past ten years behind a cell therapy product for the treatment of chronic wounds. The product is a plasma coated bandage, which delivers autologous cells (keratinoctyes) to non-healing wound beds. The account given is chronological, starting with the initial investigations of cell (keratinocyte) attachment to a range of plasma polymer surfaces. It details the subsequent selection of acrylic acid plasma polymer surfaces, on which the growth, proliferation and transfer of keratinoctyes to an in vitro wound model are studied. It concludes with the translation of this technology from the laboratory to the clinic, describing the first "proof of concept" study undertaken with non-healing diabetic foot ulcers.