A Facile Method with Low Hydrothermal Temperature to Synthesize TiO_2 as Controlled Release Drug Delivery

摘要

Titania is obtained by taking titanium oxysulfate sulfuric acid complexhydrate as Ti source with a simple, energy saving process. The effect ofhydrothermal time and temperature on morphology is investigated. Theparticle size and morphology are analyzed by X-Ray diffraction (XRD), fieldemission scanning electron microscopy (FESEM), energy dispersive X-rayspectroscopy (EDS), and Raman spectroscopy. Additionally, the effect oftetracycline/TiO_2 ratio on drug loading capacity and encapsulation rate arestudied. Zero-order kinetics, first-order kinetic, and Higuichi kinetic modelsare employed to investigate the drug release kinetics. The morphology ofas-prepared TiO_2 treated with hydrothermal temperature of 120 °C for 0.5 h ismost regular, presents microsphere shape which is composed of smallparticles with size of 19.36nm and shows high drug loading capacity(32.25±0.46%) and high encapsulation rate (47.63±1.41%) due to the largespecific surface area of 91.0629m~2 g~(-1), and it fits well with Higuichi equationwith the correlation coefficients of 0.96981, illustrating that TiO_2 hassustained release function. Therefore, this paper provides a convenient routeto prepare TiO_2 with good performance.