Chemoprevention of Colon Carcinogenesis by Oleanolic Acid and Its Analog in Male F344 Rats and Modulation of COX-2 and Apoptosis in Human Colon HT-29 Cancer Cells

Naveena B. Janakiram; Cooma Indranie; Swamy V. Malisetty; Patlolla Jagan; Vernon E. Steele; Chinthalapally V. Rao

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Chemoprevention of Colon Carcinogenesis by Oleanolic Acid and Its Analog in Male F344 Rats and Modulation of COX-2 and Apoptosis in Human Colon HT-29 Cancer Cells

机译：齐墩果酸及其类似物对雄性F344大鼠化学预防结肠癌的作用以及对人结肠HT-29癌细胞COX-2的调节和凋亡

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摘要

To assess the chemopreventive effect of oleanolic acid (ONA) and its synthetic analog 18α-olean-12-ene-3β-23,28-triol (OT) on azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) in F344 rats and understand anti-inflammatory properties and apoptosis effects in HT29 colon cancer cells and Raw 264.7 macrophage cell lines.

机译：评估齐墩果酸（ONA）及其合成类似物18α-olean-12-ene-3β-23,28-triol（OT）对F344大鼠中由乙氧基甲烷（AOM）诱导的结肠畸形隐窝灶（ACF）的化学预防作用并了解HT29结肠癌细胞和Raw 264.7巨噬细胞系的抗炎特性和凋亡作用。

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来源
《Pharmaceutical Research》 |2008年第9期|2151-2157|共7页
作者
Naveena B. Janakiram; Cooma Indranie; Swamy V. Malisetty; Patlolla Jagan; Vernon E. Steele; Chinthalapally V. Rao;
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作者单位

Department of Medicine Hem–Onc Section OU Cancer Institute University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 USA;

Department of Medicine Hem–Onc Section OU Cancer Institute University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 USA;

Department of Medicine Hem–Onc Section OU Cancer Institute University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 USA;

Department of Medicine Hem–Onc Section OU Cancer Institute University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 USA;

Chemopreventive Agent Development Research Group Division of Cancer Prevention NCI NIH Bethesda Maryland USA;

Department of Medicine Hem–Onc Section OU Cancer Institute University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 USA;

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正文语种 eng
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关键词
chemoprevention; colon cancer; COX-2; iNOS; triterpenoids;

机译：化学预防;结肠癌;COX-2;iNOS;三萜类化合物;

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专利

1. Chemoprevention of colon carcinogenesis by oleanolic acid and its analog in male F344 rats and modulation of COX-2 and apoptosis in human colon HT-29 cancer cells. [J] . Janakiram NB, Indranie C, Malisetty SV, Pharmaceutical research . 2008,第9期

机译：齐墩果酸及其类似物化学预防雄性F344大鼠结肠癌的发生以及COX-2的调节和人结肠HT-29癌细胞的凋亡。
2. Antiproliferative and apoptosis-inducing effects of maslinic and oleanolic acids, two pentacyclic triterpenes from olives, on HT-29 colon cancer cells. [J] . Juan ME, Planas JM, Ruiz-Gutierrez V, The British Journal of Nutrition . 2008,第1期

机译：马来酸和齐墩果酸（来自橄榄的两个五环三萜）对HT-29结肠癌细胞的抗增殖和凋亡诱导作用。
3. Antiproliferative and apoptosis-inducing effects of maslinic and oleanolic acids, two pentacyclic triterpenes from olives, on HT-29 colon cancer cells [J] . Hannelore Daniel, Joana M. Planas, M. Emília Juan, The British Journal of Nutrition . 2008,第1期

机译：橄榄中的两个五环三萜烯的山梨酸和齐墩果酸对HT-29结肠癌细胞的抗增殖和诱导凋亡的作用
4. Involvement of AMPK Signaling Cascade in Capsaicin-Induced Apoptosis of HT-29 Colon Cancer Cells [C] . YOUNG MIN KIM, JIN-TAEK HWANG, DONG WOOK KWAK, Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：AMPK信号级联参与辣椒素诱导的HT-29结肠癌细胞凋亡。
5. Development of a Novel Omega-6 Fatty Acid Based Treatment Strategy for Colon Cancer by Knocking Down Delta-5-Desaturase and Exploiting High COX-2 Levels in Cancer Cells/Tumors [D] . Xu, Yi 2017

机译：通过敲低Delta-5-去饱和酶并利用癌细胞/肿瘤中高COX-2水平开发一种新的基于Omega-6脂肪酸的结肠癌治疗策略
6. Arachidonic acid induces ER stress and apoptosis in HT-29 human colon cancer cells [O] . Sijeong Bae, Min-Kyoung Kim, Hong Seok Kim, 2020

机译：花生素酸在HT-29人结肠癌细胞中诱导ER应激和凋亡
7. Antiproliferative and apoptosis-inducing effects of maslinic and oleanolic acids, two pentacyclic triterpenes from olives, on HT-29 colon cancer cells [O] . Juan, M. Emilia, Planas, Joana M., Ruiz-Gutiérrez, Valentina, 2012

机译：橄榄中的两个五环三萜烯的山梨酸和齐墩果酸对HT-29结肠癌细胞的抗增殖和凋亡诱导作用

Chemoprevention of Colon Carcinogenesis by Oleanolic Acid and Its Analog in Male F344 Rats and Modulation of COX-2 and Apoptosis in Human Colon HT-29 Cancer Cells

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