Approach to the hyacinthacines: first non-chiral pool synthesis of (+)-hyacinthacine A_1

摘要

The first non-chiral pool total synthesis of (+)-hyacinthacine A_1 is described. This synthesis is based on an effective [2 + 2] cycloaddition of dichloroketene to a Stericol~(R)-based enol ether, a diastereoselective dihydroxylation, and an efficient Tam