Fully automatic segmentation of ultrasound common carotid artery images based on machine learning

摘要

Atherosclerosis is responsible for a large proportion of cardiovascular diseases (CVD), which are the leading cause of death in the world. The atherosclerotic process is a complex degenerative condition mainly affecting the medium- and large-size arteries, which begins in childhood and may remain unnoticed during decades. It causes thickening and the reduction of elasticity in the blood vessels. An early diagnosis of this condition is crucial to prevent patients from suffering more serious pathologies (heart attacks and strokes). The evaluation of the Intima-Media Thickness (IMT) of the Common Carotid Artery (CCA) in B-mode ultrasound images is considered the most useful tool for the investigation of preclinical atherosclerosis. Usually, it is manually measured by the radiologists. This paper proposes a fully automatic segmentation technique based on Machine Learning and Statistical Pattern Recognition to measure IMT from ultrasound CCA images. The pixels are classified by means of artificial neural networks to identify the IMT boundaries. Moreover, the concepts of Auto-Encoders (AE) and Deep Learning have been included in the classification strategy. The suggested approach is tested on a set of 55 longitudinal ultrasound images of the CCA by comparing the automatic segmentation with four manual tracings. (C) 2014 Elsevier B.V. All rights reserved.