β-Catenin mediates adriamycin-induced albuminuria and podocyte injury in adult mouse kidneys

摘要

Background. Glomerular slit diaphragm (SD) represents a modified adherens junction composed of molecules belonging to both immunoglobulin and cadherin superfamilies. Cadherins associate with the cytosolic scaffolding protein β-catenin, but the precise role of β-catenin in mature or injured podocytes is not known.