Back pain-a clinical challenge addressed by Mesoblast using their Mesenchymal Precursor Cells

摘要

Mesoblast is a world leader in regenerative medicine, and has built a platform technology based on the immunoselection of adult mesenchymal precursor cells (MPCs). MPCs are perivascular cells found in all vascularized tissues in the body, including bone marrow, dental pulp and adipose tissue. MPCs are the precursors of all multi-potential fibroblastoid Colony Forming Units (CFU-F), suggesting that they give rise to all the mesenchymal lineage stem cells in the tissues they reside, and which can differentiate under appropriate stimuli into bone, fat and cartilage. MPCs have specific surface markers such as STRO-1, VCAM-1 (CD106), STRO-3, STRO-4 (HSP-90b) or CD146 that facilitates their extraction and purification using the principles of antibody immunoselection.