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Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis

机译：在大型单关节炎动物模型中免疫选择的STRO-3 +间充质前体细胞减少炎症并改善临床结局

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摘要

BackgroundThe purpose of this study was to investigate the therapeutic efficacy of intravenously administered immunoselected STRO-3 + mesenchymal precursor cells (MPCs) on clinical scores, joint pathology and cytokine production in an ovine model of monoarthritis.

机译：背景本研究的目的是研究静脉注射免疫选择的STRO-3β+间充质间质前体细胞（MPC）对绵羊单关节炎模型的临床评分，关节病理学和细胞因子产生的疗效。

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期刊名称 Stem Cell Research Therapy
作者
Anwar Abdalmula; Laura M. Dooley; Claire Kaufman; Elizabeth A. Washington; Jacqueline V. House; Barbara A. Blacklaws; Peter Ghosh; Silviu Itescu; Simon R. Bailey; Wayne G. Kimpton;
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作者单位

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年(卷),期 2017(8),-1
年度 2017
页码 22
总页数 13
原文格式 PDF
正文语种
中图分类细胞生物学;医学史;
关键词
Animal model Collagen-induced arthritis Mesenchymal stem cells Neutrophils;

机译：动物模型;胶原诱导的关节炎;间充质干细胞;中性粒细胞;

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专利

1. Immunoselected STRO-3 + mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis [J] . Anwar Abdalmula, Laura M. Dooley, Claire Kaufman, Stem Cell Research & Therapy . 2017,第1期

机译：免疫选择的STRO-3 +间充质前体细胞可减轻单关节炎的大型动物模型的炎症并改善临床结果
2. Intracoronary infusion of allogeneic mesenchymal precursor cells directly after experimental acute myocardial infarction reduces infarct size, abrogates adverse remodeling, and improves cardiac function [J] . HoutgraafJ.H., DeJongR., KazemiK., Circulation research: a journal of the American Heart Association . 2013,第2期

机译：实验性急性心肌梗死后直接向异体间充质前体细胞进行冠状动脉输注可减少梗死面积，消除不良重塑并改善心脏功能
3. Intranasal Administration of Mesenchymal Stem Cell Secretome Reduces Hippocampal Oxidative Stress, Neuroinflammation and Cell Death, Improving the Behavioral Outcome Following Perinatal Asphyxia [J] . Nancy Farfán, Jaime Carril, Martina Redel, International Journal of Molecular Sciences . 2020,第20期

机译：鼻内施用间充质干细胞沉淀可降低海马氧化应激，神经炎症和细胞死亡，提高围产期窒息后的行为结果
4. UNDERSTANDING THE COMPLEXITIES OF MESENCHYMAL STEM/STROMAL CELL BIOLOGY TO IMPROVE CLINICAL OUTCOMES [C] . American College of Veterinary Surgeons Surgery^Summit . 2017

机译：理解间充质茎/基质细胞生物学的复杂性，以改善临床结果
5. Improving the clinical utility of mesenchymal stem cells through enhancing cell survival: Engineered and cellular approaches. [D] . Nuschke, Austin David. 2015

机译：通过提高细胞存活率来改善间充质干细胞的临床应用：工程和细胞方法。
6. Intranasal Administration of Mesenchymal Stem Cell Secretome Reduces Hippocampal Oxidative Stress Neuroinflammation and Cell Death Improving the Behavioral Outcome Following Perinatal Asphyxia [O] . Nancy Farfán, Jaime Carril, Martina Redel, 2020

机译：鼻内施用间充质干细胞沉淀可降低海马氧化应激神经炎症和细胞死亡提高围产期窒息后的行为结果
7. Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis [O] . Abdalmula, Anwar, Dooley, Laura M, Kaufman, Claire, 2017

机译：在大型单关节炎动物模型中，免疫选择的STRO-3 +间充质前体细胞减少炎症并改善临床结局

Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis

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