Analysis of the frequency of microsatellite instability and p53 gene mutation in splenic marginal zone and MALT lymphomas

摘要

Conclusions-These results indicate that microsatellite instability is not associated with the molecular pathogenesis of SMZL. Confirming the relatively increased fre- Quency of microsatellite instability in MALT lymphomas, and perhaps suggest- Ingthat MALT and SMZL have different Mechanisms of tumorigenesis. Aims-Studies of the genetic characteris- Tics of splenic marginal zone lymphoma (SMZL) have failed to identify genetic changes specific to this tumour.