Correlation Analysis between PIK3CA, TP53, CDH1 Genes Mutations and Breast Cancer

摘要

In the DNA sequence, accumulation of single nucleotide variation (SNV) changes the amino acid sequence of oncoprotein, and it causes normall cells to turn into cancel' cells. This study uses the 1105 samples of breast cancel' in the cBioPortal Cancel' Database to screen out three key genes, and use the electron-ion interaction pseudopotential (EIIP) of base A, base C, base G and base T to propose the E difference value formula, further verification of the impact of the three key genes on breast cancer patients. The study found that the PIK3CA, TP53 and CDHI are key genes that cause breast cancer, and PIK3CA. TP53 and CDH1 are closely related to the survival time of breast cancer.