Aldehyde Dehydrogenase and Glucose-6-phosphate Dehydrogenase as Markers for Enzyme-altered Foci in the Liver Of Dab (Limanda limanda L.)

摘要

The activities of the most important aldehyde oxidizing enzymes, the aldehyde dehydrogenases (ALDH), were detected histochemically in live cryosections of dab (Limanda limanda L.) caught a differently polluted stations along the North Sea coast. In parallel, glucose-6-phospate dehydrogenase (G6PDH) as an NADPH-generating enzyme was measured. Increased activities of both enzymes Localized putatively preneoplastic hepatocytes (foci), but ALDH in combination With propionaldehyde and NAD marked 50/100 more foci than G6PDH alone.