Bifidobacterium菌株の母子間伝播について

摘要

我々は，経膣頭位分娩で出産した児を対象に，2歳までの腸内細菌叢の縦断的動態に関する研究を行い，2歳まで有用菌であるBifidobacteriumが優勢であり，2歳の時点でも乳児期に検出率の高いB.breveが全被験者から検出されたことから，Bacteroidaceaeが優勢で, B. catenulatum groupの検出率が高い成人の腸内細菌叢とは異なっていることを明らかにした.新生児が獲得する細菌は，①出産時に母親の産道や肛門から伝播する，②出生後の空気中•衣類•寝具•食器等から伝播する，③母親の乳房の細菌が母乳を摂取する際に伝播するなどの諸説があるものの，Bifidobacteriumがどのように獲得されるかについては明らかではない.%To clarify the acquisition of the predominant Bifidobacterium strains in intestinal microbiota during infancy, we have examined the transmission between mother and child, focusing on the feces and breast milk of the mother. Because random amplification of polymorphic DNA showed that Bifidobacterium strains isolated from the feces of mother and child matched, we concluded that transmission occurred between mother and child. On the other hand, that Bifidobacterium strains were not isolated from breast milk suggests that intake of breast milk is not related to the acquisition of Bifidobacterium strains in the neonatal period. However, we recognize that transmission of bifidobacterial strains occurs. We conclude that administration of probiotics to pregnant women contributes to the acquisition of Bifidobacterium strains in the neonatal period.