Molecular Dynamics Simulations of the 30S Ribosomal Subunit Reveal a Preferred Tetracyciine Binding Site

摘要

Tetracyciine (Tc) and its analogues are important antibiotics affecting both gram-positive and gram-negative bacteria.12 Tc inhibits protein synthesis by binding to the 30S subunit of the bacterial ribosome, preventing tRNA binding to the A-site. Clinical use has led to several resistance mechanisms, including export of Tc from the cell and mutations in the bacterial rRNA. Much effort is being made to develop new Tcs that can evade resistance while effectively inhibiting protein synthesis.