Efficient synthesis of selectively protected L-dopa derivatives from L-tyrosine via Reimer-tiemann and dakin reactions

摘要

Isodittyrosine (1) is a naturally occurring dimeric amino acid that is a key structural unit of a large group of biologically active compounds, e.g., the antifungal agent piperazinomycin, K-13, and inhibitor of angiotensin I converting enzyme, the aminopeptidase B inhibitors, OF4949-I-IV, the cytotoxic hexapeptides bouvardin and Deoxybouvarding, and the antitumor antibiotics, RA-I-IV.