Petriellin A: A Novel Antifungal Depsipeptide from the Coprophilous Fungus Petriella Sordida

摘要

Antagonism between species of fungi has been frequently observed in studies of natural fungal communities. The mechanism of antagonism often involves the production by one species of antifungal agents that inhibit the growth of competitors. Our chemical investigations of antagonistic coprophilous (dung-colonizing) fungi have demonstrated that such studies can lead to discovery of novel antifungal compounds, such as the preussomerins. During our continuing investigations of these fungi, we found thatorganic extracts from cultures of Petriella sordida (UAMH 7493) exhibited potent antifungal activity. In this paper, we report the isolation and structure determination of petriellin A (1), a novel antifungal cyclic depsipeptide from P. sordida.