Inhibitory Activity of Bifidobacterium longum HY8001 against Vero Cytotoxin of Escherichia colo O157:H7

摘要

Vero cytotoxin(VT)-producing Escherichia coli(VTEC), such as E.coli O157:H7, are emerging fooborne pathogens worldwide. VTs are associated with hemorrhagic colitis and hemolytic uremic syndrome in humans. Attachment of the B subunit of VTs to its eceptor, globotriaosylceramide(Gb_3), at gut epithelium is the primary step and, consequently, the A αand inerleukin(IL)-1β, up-regulate Gb_3 expression, increase sensitivity to VTs and enhance VT action in developing disease.