Merkel cell carcinoma can be distinguished form metastatic small cell carcinoma using antibodies to ctokeratin 20 and thyrodi transcription factor 1

摘要

Aim-To investigate whether immuno- histochemical staining for cytokeratin 20 (CK20) and thyroid transcription factor 1 (TTF-1) is useful in distinguishing Merkel cell carcinomas (MCCs) from metastatic small cell carcinomas (SCCs). Methods-Eleven cases of MCC and 10 of Lung SCC were stained for CK20 and TTF-1. Results-Ten of 11 MCCs stained with the Antibody to CK20. None was positive for TTF-1. No SCC stained with anti-CK20 And all stained strongly with anti-TTF-1. Conclusions-the use of both anti-CK20 And anti-TTF-1 can reliably distinguish Between MCC and metastatic SCC, thus Avoiding the need for a detailed clinical Investigation of patents with MCC in Whom metastatic SCC must be excluded.