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首页> 外文期刊>Journal of Cancer Research and Clinical Oncology >EGF-R and Her2eu overexpressing tumors: independent collectives for treatment of breast cancer by specific monoclonal antibody-therapy
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EGF-R and Her2eu overexpressing tumors: independent collectives for treatment of breast cancer by specific monoclonal antibody-therapy

机译:EGF-R和Her2 / neu过表达的肿瘤:通过特异性单克隆抗体疗法治疗乳腺癌的独立组织

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摘要

In our recent studies, we demonstrated that breast cancer treatment by anti-EGF-R antibody resulted in a significant therapeutic effect in vivo. Furthermore, we were able to elucidate histopathologic parameters with an impact on therapy success. The aim of this study was the evaluation of EGF-R and Her2eu protein expression on a large series of primary breast cancer, to elucidate if anti-EGF-R antibody therapy is a new therapeutic option for patients who are Her2eu negative and where, therefore, anti-Her2eu antibody treatment is not applicable.
机译:在我们最近的研究中,我们证明了抗EGF-R抗体对乳腺癌的治疗在体内产生了显着的治疗效果。此外,我们能够阐明组织病理学参数对治疗成功的影响。这项研究的目的是评估大量原发性乳腺癌中EGF-R和Her2 / neu蛋白的表达,以阐明抗EGF-R抗体疗法是否是Her2 / neu阴性患者的新治疗选择因此,抗-Her2 / neu抗体治疗不适用。

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